Abstract
Background: Pneumonia is the second most common nosocomial infection among critically ill patients, affecting 27% of all critically ill patients.
 Methods: The study was conducted in an intensive care unit (ICU) of a tertiary care centre. A total of 100 patients who were kept on mechanical ventilator were randomly selected. Cases included were patients of both sexes who were kept on mechanical ventilator for more than 48 h, having the age of >15 years. Patients who died or developed pneumonia within 48 h or those who were admitted with pneumonia at the time of admission and patients of ARDS (Acute Respiratory Distress Syndrome) were excluded from the study.
 Results: The mean duration of mechanical ventilation was found to be 12.3±3.1 days for the non-VAP group and 19.1 ±4.2 days for the VAP group that those requiring prolonged ventilator support (>15 days) had a significantly higher incidence of VAP (P-value, 0.001). Supine position and stuporous, comatose patients were found to be risk factors, having a high incidence of VAP, and proved to be statistically significant.
 Conclusion: Incidence is directly proportional to duration of mechanical ventilation and re-intubation is a strong risk factor for development of VAP. Therefore, duration of ventilation has to be reduced to get rid of morbidity and mortality associated with mechanical ventilation, which can be achieved by administering a proper weaning protocol and titrating sedation regimens as per the need of the patients.
 Keywords: Incidence, Infection, ICU
Highlights
Pneumonia is the second most common nosocomial infection among critically ill patients, affecting 27% of all critically ill patients.[1]
The study was conducted in an intensive care unit (ICU) of a tertiary care centre
Patients who died or developed pneumonia within 48 h or those who were admitted with pneumonia at the time of admission and patients of ARDS (Acute Respiratory Distress Syndrome) were excluded from the study
Summary
2 Ventilator associated pneumonia (VAP) refers to hospital acquired pneumonia that occurs within 48 hours or longer after mechanical ventilation (MV). Pneumonia is the second most common nosocomial infection among critically ill patients, affecting 27% of all critically ill patients.[1] It is one among the leading cause of morbidity and mortality among the hospital acquired infections. VAP is the second most common nosocomial infection in the intensive care unit (ICU) and the most common in mechanically ventilated patients. Conclusion: Incidence is directly proportional to duration of mechanical ventilation and re-intubation is a strong risk factor for development of VAP.
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