Abstract
THE concentration (“trapping”) of iodide by the thyroid is one of the most specific functions of this gland and constitutes the first step in thyroid hormone biogenesis. If the subsequent organic binding of iodine is blocked with thiouracil, the thyroid: serum iodide concentration ratio (T/S) can be determined (Vanderlaan and Vanderlaan, 1947). These authors found the T/S of normal rats to be around 25:1. The following findings indicated that the thyroidal iodide trap is profoundly influenced by thyrotrophin (TSH): a) In rats made goitrous by the chronic administration of propylthiouracil (PTU) the T/S rose to an average value of 250:1 (Vanderlaan and Vanderlaan, 1947); b) After hypophysectomy PTU did not have such an effect and the T/S of hypophysectomized, PTU treated rats was found to be around 6:1 (Greer, 1949); c) A single dose of TSH, given to normal rats, caused a transient rise in the T/S (Vanderlaan and Greer, 1950).
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