Abstract
Two experimental approaches were used to study the effect of chronic antidepressant treatments on the functioning of central alpha2-adrenoceptors. In one, the effect of antidepressant treatment on the ability of a low dose of clonidine (25 μg/kg) to lower rat brain 3-methoxy-4-hydroxyphenylethyleneglycol sulphate (MHPG-SO4) levels was studied. In the other, potential treatment-induced alterations in rat frontal cortex 3H-clonidine binding were determined. The same cortical tissue was also studied in parallel for 3H-dihydroalprenolol binding.
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