Abstract
Plasma renin activity and urinary aldosterone excretion were studied in three infants with salt-losing adrenogenital syndrome and one child with the non-salt-losing variety under conditions of salt loading or deprivation. Plasma renin activity was greatly elevated in one infant with SL-AGS on the first day of life, whereas aldosterone excretion was low. This infant and another with SL-AGS had elevated blood pressure, possibly secondary to the high plasma renin activity. All four patients had exaggerated plasma renin activity responses to sodium depletion. Aldosterone excretion rates, although lower in the three infants with SL-AGS, were also low in the child with NSL-AGS and did not respond to salt deprivation. On the basis of these studies, one cannot adequately distinguish between salt losers and non-salt losers by measurements of plasma renin activity and urinary aldosterone excretion.
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