Abstract
1. The immunogenic activity of FMDV suspensions is associated with a component which sediments in sucrose gradients at ca. 140S and has a buoyant density in caesium chloride of 1.43 g/ml. The infective component of the virus gives the same values under similar conditions. 2. Particles sedimenting at 140 S in sucrose gradients but having a density greater than 1.43 g/ml are produced by storage or under certain conditions of inactivation. These particles are not immunogenic. 3. The loss of immunogenicity is proportional to the change in density and is probably due to the progressive loss of protein from the virus coat.
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