Abstract
Dyslipidemia, defined as abnormal levels of plasma lipids, is an independent risk factor for cardiovascular diseases, and is increasing worldwide. Methylglyoxal (MG), a reactive glucose metabolite, is a causative factor for type 2 diabetes and is associated with hypertension. We have recently reported abnormal plasma lipid levels in Sprague–Dawley (SD) rats treated chronically with MG. The aim of this study was to explore the possible mechanism(s) of MG-induced dyslipidemia. MG (60mg/kg/day) or 0.9% saline was administered to 12-week-old male SD rats by continuous infusion with a minipump for 28days, and thereafter the plasma, liver and adipose tissue were collected.
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