A Study of the Inosine–Sodium Hydroxide–Water and Inosine–Potassium Hydroxide–Water Systems

Abstract

Abstract Solubility data have been obtained for the inosine–NaOH–H2O and inosine–KOH–H2O systems at 30 °C. Two different solid phases of the potassium salt of inosine (C10H11N4O5·K·H2O and C10H11.5N4O5·0.5 K·0.5 H2O) were found in the latter system, while only one solid phase of the sodium salt of inosine (C10H11N4O5·Na·2.5 H2O) was found in the former system. The hemi-potassium salt of inosine is incongruent and is decomposed by pure water, whereas the mono-alkaline-metal salts are stable. The solubilities of the two mono-alkaline-metal salts of inosine in water were determined at 0–50 °C and formulated as follows: Na-salt, logS & = 0.01359·t+0.3997 K-salt, logS & = 0.00733·t+1.6513 where S represents the gram weight of the anhydrous salt per 100 g of water. The X-ray powder diffraction data of the above three salts are given.