Abstract
The aim of this study was to increase the solubility and dissolution rate of naproxen (NAP) by inclusion complex formation with β-cyclodextrin (β-CD). The solubility of NAP with β-CD in aqueous solution was determined. The apparent stability constant, K c, was calculated from the slope and intercept of the AL solubility diagram as 568 M −1. The solid complexes of NAP with β-CD in 1:1 molar ratio were prepared by the freeze-drying and neutralization method. The formation of an inclusion complex with β-CD in solid state was confirmed by X-ray diffractometry, IR spectroscopy and differential scanning calorimetry (DSC). The dissolution rate of NAP from the inclusion complex was much more rapid than of NAP alone. The amount of NAP released from the tablet surfaces was determined for tablets pressed under 3500 kg/cm 2. It was seen that the total released amount of NAP from the NAP/β-CD complex was greater than that of intact NAP.
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