Abstract
The content of Furocoumarin derivatives (Psoralens) of Ruta Chalepensis L. (Whole plant) was studied by simple extraction with petroleum ether (b.p. 60-80Co). The results indicated that the plant contains a total of about (0.015%).
 Investigation of these compounds by thin layer chromatography (TLC) revealed the presence of at least four compounds of which methoxsalen (8-methoxypsoralen) was isolated. It was identified and authenticated with a standard by spectral method, IR, NMR, Mass spectra and HPLC.This plant could be considered as a good source for supplying this compound, which is widely used in dermatological preparations.
Highlights
Ruta Chalepensis L. (Rutaceae) is a cultivatec plant [1] widely grown as garden ornamentals in Baghdad and its vicinity
Literature survey revealed that Ruta chalepenis L., contains many important components[3,4,5,6,7,8,9], among w hich are coumarins and Furocoumarin derivatives.Since no previous work has been done on this
A quantity of 20 gm of the residue was dissolved in a minimum amount of chloroform and applied together with standard psoralen reference compounds on a number of preparative thin layer chromatography (TLC) plates of silica gel GF254 (0.75 mm thickness) and developed with solvent system benzeneacetone (90:10 v/v)
Summary
Ruta Chalepensis L. (Rutaceae) is a cultivatec plant [1] widely grown as garden ornamentals in Baghdad and its vicinity. Iraqi plant was found that study of these compounds, is of advantage for its economical value and uses in dermatological preparations, as available imported ones are very expensive. A quantity of 20 gm of the residue was dissolved in a minimum amount of chloroform and applied together with standard psoralen reference compounds (methoxsalen and imperatorin) on a number of preparative TLC plates of silica gel GF254 (0.75 mm thickness) and developed with solvent system benzeneacetone (90:10 v/v).
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Schedule a callMore From: Iraqi Journal of Pharmaceutical Sciences ( P-ISSN: 1683 - 3597 , E-ISSN : 2521 - 3512)
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