A STUDY OF THE FIBRINOLYTIC ACTIVITY IN PULMONARY TUBERCULOSIS

Abstract

Author studied the fibrinolytic activity of preoperative systemic venous blood and that of systemic and pulmonary venous blood during operation. and reviewed the relationship between the fibrinolytic activity and the clinical findings. in 47 cases of pulmonary resection for pulmonary tuberculosis.The results were as followings: 1. In pulmonary tuberculosis, the preoperative positive cases of fibrinolytic activity test were 32%, and it was significant compared with the other pulmonary lesions. 2. During operation, the fibrinolytic activity of systemic venous blood was moderately positive in 36% of the cases. but that of pulmonary venous blood was moderately or highly positive in all cases. 3. In systemic venous blood, nearly all of the preoperative negative fibrinolytic cases were negative during operation. but in the Pulmonary venous blood, all cases were posítíve.4. The preoperative positive fibrinolytic activity cases in systemic venous blood, were moderately accentuated in fibrinolytic activity during operation but in pulmonary venous blood, all cases were markedly accentuated. 5. It revealed that the extent of the lung parenchyma destruction was proportional to the accentution of the positive fibrinolytic activity.6. In preoperative positive fibrinolytic activity cases, the amount of post-operative abnormal bleeding was significantly increased compared with the preoperatively negative cases.7. It seemed that the preoperative administration of anti-plasmin agents (such as E-ACA) had An effect upon the reduction of the amount of postoperative e bleeding.8. The preoperative fibrinolytic activity test might be very helpful in preventing the postoperative abnormal bleeding.