Abstract
Background: Hepatitis B virus is an enveloped, partially double-stranded DNA virus belonging to family Hepadnaviridae, genus Orthohepadnavirus. Chronic infection results in slowly progressive liver disease that can lead to cirrhosis, chronic liver failure, and hepatocellular carcinoma (HCC). Chronic Hepatitis B infection is dened by the continued presence of HBsAg in the blood for longer than six months. Chronic liver disease (CLD) is a progressive deterioration of liver functions, leading to brosis and cirrhosis, over more than six months. Aims: To assess the prevalence and incidence, mortality, complications of Hepatitis B infection in Chronic Liver Disease. Materials And Methods: This is a prospective observational study of 535 patients of clinically suspected Chronic liver Disease conducted from January 2021 to June 2022. Patient's detailed case history was taken, and blood or serum samples were tested for HBsAg by ELISAN using Merilisa HBsAg kits. Results: Of 535 samples 79.4% were Male while the 20.6 % female. Maximum number of patients were in the age group 41 to 60. Increased alcohol consumption was the most common risk factor. 25.04% tested reactive to HBsAg where 86.56% were male and 13.43% female. 29.85% cases progressed to Cirrhosis while 0.75% had Hepatocellular Carcinoma. The in-hospital mortality was 9.52 %. The mortality rate among HBsAg seropositive cases was 30.59%. The incidence and prevalence of HBsAg reactivity among the patients of Chronic Liver Disease seen in the patients of this study in the study duration was 21.12 % and 25.46% respectively
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