A STUDY OF THE EFFECT OF TIME RESTRICTED MEAL INTAKE ON ANTHROPOMETRIC AND BIOCHEMICAL PARAMETERS IN PATIENTS OF TYPE 2 DIABETES

Abstract

Objective: 1. To study effect of time restricted meal intake on anthropometric and biochemical parameters in Type 2 diabetes patients. 2. To study if time restricted meal intake can act as an adjunct along with the standard conventional treatment of diabetes in patients of Type 2 diabetes mellitus. Design and method: 384 Type 2 diabetes patients enrolled from OPD Endocrinology, King George's Medical University were randomly divided based on whether the patients consented to having early dinner TRM (time restricted meal) group (192 patients) or not (control group) (192 patients). Follow up was done at 6 and 12 months for anthropometric measurement, height, weight, waist hip ratio, neck size, fasting, post prandial blood sugar, HbA1c, serum urea, serum creatinine and lipid profile. The patient was given a clear understanding about chronomedicine. A single intervention was done - timing of dinner was at or around 7 pm in the evening for TRM group. Both groups were given standard conventional treatment of diabetes. Result: 65% of TRM group, 40 % (non- TRM) had normal HbA1c after 12 months. BMI, Hip size, systolic blood pressure, HbA1c, blood sugar (fasting and post- prandial) were significantly different (p < 0.05) in TRM Group as compared to the p value of control group. p value <0.0167 observed in values of blood sugar (fasting) in TRM Group, p value < 0.8113 in control group. Blood sugar (post- prandial) in TRM Group a p value <0.0001 (highly significant), control group p value<0.6938. Hip size (TRM Group) p value < 0.0012 (Significant) (Difference between means=2.762 ± 1.261). BMI (TRM Group) p value = 0.0030, significant. Neck Size (TRM Group) p value= 0.9697, not significant. Waist Size (TRM Group)p value= 0.2832, not significant. Hip Size (TRM Group) p value = 0.0012, significant, correlation coefficient=0.8380. Systolic Blood Pressure (TRM Group) p value = 0.0211, significant. Diastolic Blood Pressure (TRM Group) p value = 0.536, not significant. Results: One of the first studies which has been undertaken in Indian diabetics, although the initial data obtained is encouraging yet further study is required to corroborate results.