Abstract
Aerial parts of Phyllanthus amarus are used by Traditional Healers of Tanga, northeastern Tanzania, to control symptoms of non-insulin dependent diabetes mellitus (NIDDM). An aqueous extract of the aerial parts, 0.1 and 1 g/kg body weight, significantly enhanced clearance of glucose from the blood as compared to controls during an oral glucose tolerance test (OGTT), using normal fasted albino rabbits (P = 0.05). The two doses of the extract reduced the area under the OGTT curve by 7.8% and 11.4%, respectively. Both doses had no effect on blood glucose in the unfed rabbits. Chlorpropamide, 0.1 g/kg body weight, showed a greater effect, than both doses, on glucose clearance in the fed state and on blood glucose in the fasted rabbits (P = 0.05). A methanol extract of the aerial parts, 1 g/kg body weight, worsened glucose tolerance causing a significant increase in area under the OGTT and fasting blood glucose curves (P = 0.05). We conclude that the aqueous extract contains a hypoglycaemic activity as claimed...
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