A Study of the effect of Octreotide and N-acetylcysteine on inflammatory and prognostic parameters in severe acute pancreatitis in rats

Abstract

Acute pancreatitis (AP) is a common emergency presentation and can be disabling. There is significant morbidity and mortality associated with AP, and it places a considerable burden on the healthcare system. Octreotide and N-acetylcysteine have been shown to have a protective effect in induced severe acute pancreatitis in rats. This study aim to clarify the protective potential effect of these two medications on the prognostic and inflammatory parameters in severe acute pancreatitis in rats. 40 adult male rats were allocated to five groups (n=8), control group, AP group, octreotide group, NAC group, combination group. Rats with severe acute pancreatitis have significant (p>0.05) higher levels of lipase, PMN elastase, urea, IL-1s and significant (p>0.05) lower levels of TAC as compared with control group. Rats treated by octreotide and NAC have significant lower levels of lipase, PMN elastase, urea, IL-1s and significant (p>0.05) higher levels of TAC as compared with AP group. Furthermore octreotide has antioxidant and anti-inflammatory activity better than NAC. Prognostic markers are possible predictors of outcome, we found that PMN elastase is a good early predictor and start to peak in the first hours of the disease faster than urea, they are positively correlated with the severity of the disease also the protective effects of Octreotide treated group were more than those carried out in NAC treated group.