Abstract
Absorption, excretion, and metabolism of radiolabeled (C14) Imidan® ( O,O -dimethyl S -phthalimidomethyl phosphorodithioate) were studied in a steer after dermal application. Imidan was moderately absorbed by the skin of the steer, since 9.6% of the applied dose was recovered in the excreta within 7 days. The compound was rapidly broken down in the blood system, as indicated by the small percentage of radioactivity which could be extracted with chloroform (less than 2%). The principal route of elimination of absorbed material was through the urine, in which nearly 8% of the applied dose was found within 7 days. Paper chromatography and electrophoresis of urine samples indicated that the primary degradation of Imidan in the steer occurred at the nitrogen atom, resulting in the almost exclusive production of phthalic and phthalamic acids. The presence of benzoic acid as a metabolite was not conclusively proved. The systemic action against common cattle grubs, Hypoderma lineatum (de Villers), is evidently the result of very low concentrations of Imidan or the oxygen analogue.
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