Abstract
The glycosaminoglycans (acid mucopolysaccharides, GAGs) of the loose connective tissue in human dental pulp and rat and rabbit incisor pulps were separated and semi-quantitated by means of cellulose-acetate membrane electrophoresis on a micro-scale. The average total amount of GAGs present in these pulps, measured as uronic acid, was 0.55, 0.36 and 0.64 μ/mg wet tissue weight in the human, rat and rabbit pulps respectively. In the rat and rabbit tissues, the most abundant GAG fraction was chondroitin sulphate. Hyaluronate was also present in considerable quantity. A minor fraction with the electrophoretic mobility of keratan sulphate or heparan sulphate was also seen. In erupted human teeth pulps in which dentinogenesis was complete, hyaluronate normally accounted for more than half of the GAGs. Dermatan sulphate was present in large quantities, while chondroitin sulphate was a minor fraction. The possible functions of the GAGs in these tissues are discussed. As pulps undergoing active dentinogenesis contain large amounts of chondroitin sulphate, the role of this fraction in hard tissue deposition is discussed. The advantages of the rat and rabbit incisor pulps for the study of loose connective tissue biology and the mineralization process are also mentioned.
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