Abstract
BackgroundLymph node metastasis is a major prognostic sign of colorectal carcinoma and an important indicator for individualized treatment. M2 macrophages play a key role in carcinogenesis and tumor development by enhancing invasiveness and promoting lymph node metastasis. The purpose of this study was to investigate the effect of CD163-positive M2 macrophages on lymph node metastasis in colorectal carcinoma.MethodsPostoperative lymph node tissues were obtained from 120 patients with colorectal carcinoma who underwent radical surgery in the First Affiliated Hospital of Jinzhou Medical University between December 2019 and May 2020. We detected the expression of the CD163 protein in lymph nodes using immunohistochemistry. Furthermore, the relationships between M2 macrophages identified by expression of CD163 and lymph node metastasis were analyzed using the independent sample t-test and Chi-square test.ResultsM2 macrophages were increased in metastatic lymph nodes and non-metastatic lymph nodes adjacent to the cancer. The M2 macrophage count was higher in patients with macro-metastases than in patients with micro-metastases.ConclusionsThe presence of M2 macrophages represents an important indicator for lymph node metastasis in colorectal carcinoma and may be a potential marker for its prediction. Thus, M2 macrophage localization might offer a new target for the comprehensive treatment of colorectal carcinoma.
Highlights
Colorectal carcinoma (CRC) is one of the most common malignant tumors worldwide, ranking third globally, with an annual incidence of approximately 1.2 million people
Studies have shown that among these individual components, M2 macrophages play an essential role in promoting tumor growth, angiogenesis, lymphangiogenesis, immune tolerance, and anti-tumor immunity, and CD163 is a specific marker for these cells [6, 7]
Relationships between clinicopathological parameters and lymph node metastasis in colorectal carcinoma patients As seen in Table 2, LNM in colorectal carcinoma patients was correlated with the degree of tumor differentiation, depth of invasion, and preoperative CEA, CA199, and CA724 levels (P0.05)
Summary
Colorectal carcinoma (CRC) is one of the most common malignant tumors worldwide, ranking third globally, with an annual incidence of approximately 1.2 million people. The presence or lack of local lymph node metastasis (LNM). Studies have shown that among these individual components, M2 macrophages play an essential role in promoting tumor growth, angiogenesis, lymphangiogenesis, immune tolerance, and anti-tumor immunity, and CD163 is a specific marker for these cells [6, 7]. Lymph node metastasis is a major prognostic sign of colorectal carcinoma and an important indicator for individualized treatment. M2 macrophages play a key role in carcinogenesis and tumor development by enhancing invasiveness and promoting lymph node metastasis. The purpose of this study was to investigate the effect of CD163-positive M2 macrophages on lymph node metastasis in colorectal carcinoma
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