Abstract
This work was carried out to compare between the anticoccidial efficacy of clopidol and garlic powder. Three groups of one day old Hubbard chicks each of 30 birds were used in this study. The 1st group received only basal ration (control). The second group received clopidol 125 mg/ kg B.W. The third group received garlic powder 5 gram /kg B.W. Birds in all groups were infected with a field stain of Eimeria spp. (50.000 oocysts / bird) at 21 days of age. Mortality rate and clinical signs of coccidiosis were recorded. Also, oocyst count/gm faeces, body weight gain and feed conversion were measured at 7th, 14th and 21 th day after challenge. Five birds in each group were killed one week post infection and lesion score was determined. Blood samples were collected from birds of each group at the end of experiment for detection of serum levels of AST, ALT, creatinine and uric acid. The obtained data demonstrated that administration of clopidol or garlic powder evoked a significant decrease in mortality rate, oocyst count/gm droppings, lesion score and clinical signs of coccidiosis, compared with infected non treated group. Also, adding of clopidol or garlic powder improved the performance of the birds. The serum level of AST, ALT, createnine and uric acid was decreased by both treatment. It was noticed that addition of garlic powder induce more prominent effects than clopidol in improving the feed conversion (at 21 day post infection) and serum creatinin level and decreasing the mortality rate. On the other hand, clopidol treated group had a lower oocysts count/ gm droppings (1st and 2nd week post infection) compared with other groups.
Highlights
Coccidiosis remains one of the most expensive and common diseases of poultry in spite of advances in chemotherapy, management, nutrition and genetics. (Cox, 1998 and Ernik and Bedrnik, 2001)
Clopidol is one of the anticoccidial drugs acts by inhibiting coccidial respiration by interfering with cytochrome-mediated electron transport in the parasites mitochondria (Fry and Williams, 1984; Long 1993; Adam, 2001 and Walter, 2008)
The obtained data concerning the effect of clopidol and garlic powder on the chickens infected with Eimeria spp. revealed that administration of clopidol or garlic powder evoked a significant decrease in oocyst count/gm droppings, lesion score, clinical signs of coccidiosis and mortality rate compared with infected non treated group
Summary
Coccidiosis remains one of the most expensive and common diseases of poultry in spite of advances in chemotherapy, management, nutrition and genetics. (Cox, 1998 and Ernik and Bedrnik, 2001). (Cox, 1998 and Ernik and Bedrnik, 2001) It leads to the extensive destruction of the intestinal epithelium which results in reduced food efficiency and body weight gain, as well as a temporary reduction in egg production (Min et al, 2004 and Dalloul and Lillehoj 2005). This has a considerable economic loss at the level of poultry industry. This was reported by Bahadoran et al (2013)
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