Abstract
Objective: Till date, a very few prospective studies have examined the association between serum homocysteine levels and the risk of stroke and stroke subtypes in Indian populations. Methods: A prospective, case - control study of Indian subjects 10–90 years of age was conducted using frozen serum samples from 103 participants in cardiovascular risk surveys collected from December 2017 to November 2018. By the end of 103, we identified 55 incidents of severe strokes, one control subject per case was selected by matching for sex, age, community, year of serum storage, and fasting status. Serum total homocysteine levels were measured by Cobas c-311. Results: Compared with control subjects, total (n_206), hemorrhagic (n_106), and ischemic (n_87) strokes had higher geometric mean values of total homocysteine and higher proportions of homocysteine −25.0 μ mol/L. Homocysteine was estimated after adjustment for body mass index, smoking, alcohol intake, hypertension, and other cardiovascular risk factors. The excess risk of total and ischemic strokes did not vary significantly according to sex, age, smoking status, or hypertensive status. Conclusion: High total homocysteine concentrations were associated with the increased risk of total stroke, more specifically ischemic stroke) Capsuloganglionic and frontoparietal infarct (8 each)., among Indian men and women.
Highlights
High levels of homocysteine, in fasting or non-fasting state, have been reported to be more prevalent in patients with stroke as opposed to control subjects [1,2]
One hundred and two ischemic stroke incidents were identified during follow-up
Intake of alcohol was higher in cases in comparison to control subjects for all stroke patients
Summary
In fasting or non-fasting state, have been reported to be more prevalent in patients with stroke as opposed to control subjects [1,2]. We hypothesized a priori that the risk of ischemic stroke was increased by hyperhomocysteinemia, right front-parietal infarct, left cerebella infarct, but not the risk of hemorrhagic stroke among Indian men and women. To test this hypothesis, we conducted a prospective, casecontrol study including men and women belonging to the southern population of Rajasthan, India, using stored serum samples
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