Abstract
Hyperuricemia as a predictor in COPD and Exacerbation. The study aims to measure serum uric acid levels in patients with chronic obstructive pulmonary disease as a predictor. Materials and Methods: It is an observational study done on 50 COPD patients newly diagnosed or previously diagnosed. Serum uric acid level, chest x-ray and pulmonary function tests were performed with consent. Results: The mean normal Serum uric acid (mg/dl) was 4.86+ 1.6. The increased mean serum uric acid (Hyperuricemia) was 9.67+ 1.8. The mean serum urea and creatinine levels were 26.74+3.91 and 0.94+0.20. The FEV1% Predicted in Normal UAC – 51.8+18.6 and in cases of Hyperuricemia 53.4+16.7. FVC% Predicted in Normal UAC was 77.5+17.8 in cases of Hyperuricemia it was 76.5+18.5. Conclusion: The outcome of our study shows serum uric acid is cost-effective, easy and non-invasive and possibly suitable in assessing the patient disease severity, progression to exacerbation. Keywords: COPD, Serum uric acid, Hyperuricemia, Predictor.
Highlights
Chronic obstructive pulmonary disease (COPD) is a disease causing limitation of airflow due to inflammation of airways with parenchymal destruction and subsequent emphysema formation
Hyperuricemia is associated with an increased risk of coronary heart disease, comorbidity that is relevant for mortality in COPD patients.[8,9]
Out of 50 study participants, 39 were males, which is significantly higher than the females (
Summary
Chronic obstructive pulmonary disease (COPD) is a disease causing limitation of airflow due to inflammation of airways with parenchymal destruction and subsequent emphysema formation. Serum uric acid is the final product of purine degradation, which increases significantly during hypoxia.[2,3] Elevated uric acid levels have been associated with the presence of systemic inflammation and increased cardiovascular risk.[4,5] In this context, increased levels of uric acid have been shown in respiratory disorders, including obstructive sleep apnoea and pulmonary hypertension.[6,7]. The worse outcome of COPD patients with hyperuricemia seems to involve several factors including systemic inflammation, oxygen desaturation and lung function alterations. Hyperuricemia is associated with an increased risk of coronary heart disease, comorbidity that is relevant for mortality in COPD patients.[8,9]. Some data exist on the significance of serum uric acid in patients with COPD, few more studies are warranting to add the evidence. The study aims to measure serum uric acid levels in patients with chronic obstructive pulmonary disease as a predictor in staging
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