A STUDY OF SERUM LDL CHOLESTEROL IN RELATION TO SEVERITY OF ISCHAEMIC CEREBROVASCULAR ACCIDENT

Abstract

Background: Cerebrovascular disease is a major public health problem with significant mortalities and morbidities. Cerebrovascular diseases include some of the most common and devastating disorders: ischemic & hemorrhagic strokes.The incidence of cerebrovascular accident increases with age and the number is projected to increase as the elderly population grows,with a doubling in stroke death in United States by 2030. Ischemic stroke is caused by vascular occlusion,which may be due to emboli or thrombus.Ischemic stroke is responsible for 50-85% of all strokes worldwide1. Distribution of risk factors and their influence on ischemic stroke may vary depending upon the geographical area and cultural background. In our centre Gauhati Medical College and Hospital, a tertiary care hospital where patients from different corners of the state are referred,is representative of different ethnic, social and cultural background.There is paucity of data regarding this topic in our region. Therefore, we have taken up this study to look for spectrum of lipid profile abnormalities, specifically serum LDL cholesterol, in acute ischemic stroke.Aim: To study severity of ischemic stroke in relation to serum LDL cholesterol.Methods And Materials:This hospital based observational study recruited 150 patients of age more than 18 years admitted under Medicine,Neurology and Emergency departments of GMCH with ischemic stroke from 1stJune 2020 to 31st May 2021. Results: Out of 150 patients, severity of stroke is more in patients whose serum LDL Cholesterol is high.It has shown that minor stroke seen in patients with normal LDL level,(HIGH LDL=0, NORMAL LDL=8), Moderate stroke seen in NORMAL LDL=82 and HIGH LDL=51 patients & moderate to severe stroke seen in patients with only HIGH LDL cholesterol NORMAL LDL=0 and HIGH LDL=9.The relation between severity of stroke & raised S. LDL cholesterol is found to be significant with p Value of 0.001. Conclusion: Our study showed a definite positive correlation between Serum LDL cholesterol abnormality and ischemic stroke.