Abstract
Background: Stroke/cerebrovascular accident (CVA) is the second most common cause of mortality after coronary artery disease (CAD). Amongst all neurological diseases, stroke ranks first in frequency and importance. In India, the scenario is no different, its incidence and prevalence are on a steady rise. To evaluate the concentration of serum ferritin in patients of acute stroke as a prognostic marker.
 Methods: This was a hospital based observational and cross sectional study conducted on 60 cases of acute stroke as per seed article having minimum difference of mean (f ferritin level) 365 and 145.43 for 80% power and 0.05 alpha error.
 Results: Out of 34 cases of haemorrhagic cases 13 cases mortality was observed while 14 cases had deteriorated outcome and 15 cases improved. Mean serum ferritin of dead, deteriorate and improved haemorrhagic cases was 1169±114.28, 723.07±88.07 and 107.43±26.80. Serum ferritin level was abnormal [raised] in all 22[36%] death cases and 24[40%] cases who had deteriorate.
 Conclusion: Elevated serum ferritin is strongly associated with early neurological deterioration in patients of stroke and is a definite poor prognostic marker of acute stroke [ ischemic or haemorrhagic] an elevated serum ferritin (A marker of iron stores) herald more intensive management protocols and care for the patient as it can predict early neurological deterioration. Iron chelation therapy in acute stroke seems to be a strong theoretical possibility and further studies are required to investigate its role in treatment of stroke.
 Keywords: Stroke, Prognostic Marker, Elevated serum ferritin
Highlights
Stroke/cerebrovascular accident (CVA) is the second most common cause of mortality after coronary artery disease (CAD)
Indian Collaborative Acute Stroke Study (ICASS); a multi-centric study conducted among 2,162 admitted stroke patients across southern, northern, and western India observed ischemic stroke in 77%, haemorrhagic stroke in 22%, and unspecified stroke in 1% cases; a statistics similar to the global trend[7] In India, the scenario is no different, its incidence and prevalence are on a steady rise
Neurological assessment was repeated on 6th day of admission by Canadian stroke scale and patients were classified into three categories namely clinical improvement, deterioration and death on basic CANADIAN STROKE SCLAE score
Summary
Stroke/cerebrovascular accident (CVA) is the second most common cause of mortality after coronary artery disease (CAD). The very low prevalence rates of stroke in these studies led to the belief that stroke was less frequent in India than in the Western countries. Over the last two decades the crude stroke prevalence in different parts of India ranges from 44.29 to 559/1,00,000 persons which is significantly higher as compared to the western data[4]. To evaluate the concentration of serum ferritin in patients of acute stroke as a prognostic marker. Methods: This was a hospital based observational and cross sectional study conducted on 60 cases of acute stroke as per seed article having minimum difference of mean (f ferritin level) 365 and 145.43 for 80% power and 0.05 alpha error. Mean serum ferritin of dead, deteriorate and improved haemorrhagic cases was 1169 114.28, 723.07 88.07 and 107.43 26.80.
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