Abstract
The extent of plasma protein-binding of 99 m Tc-methylene diphosphonate (MDP) at 10 min, 1, 2 and 3 h after injection into patients has been determined by trichloroacetic acid and ammonium sulfate precipitation, dialysis and Sephadex gel chromatography. The percent administered dose bound to plasma proteins decreases with time, whereas the fraction of the plasma activity bound to plasma proteins increases with time after injection. Urinary excretion of the tracer is about 38% at 2 h and 62% at 24 h. The results suggest that the rate of removal of 99 m Tc-MDP by bone uptake and urinary excretion is much faster than the rate of disappearance of the protein-bound tracer.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: International Journal of Nuclear Medicine and Biology
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
