A Study of Prognostic Predictors in Organophosphate Poisoning in a Critical Care Unit of a Medical College of Andhra Pradesh

Abstract

Background : Diagnosis of organophosphate poisoning is purely clinical, through some biochemical test will help in diagnosis of organophosphate poisoning. There is no specific prognostic predictor in terms of duration of hospital stay and course of recovery. Good prognostic predictor can guide the clinician for further treatment. Objectives : 1. To study the prognostic predictor with special reference to duration of the hospital stay. 2. To predict duration of hospital stay from initial clinical sign and biochemical parameters. Materials and method : Around 240 patients of organophosphate poisoning who were admitted in the critical care unit in the hospital from January 2007 to January 2010 were examined, investigated and interview with help of semi structured proforma. The initial clinical presentation and biochemical parameter were recorded for the study. Result: Patients who presented clinically with severe symptoms at the time of admission, increased leucocytes counts, electrolytes and low serum acetyl choline esterase level, those patients stayed more days in ICU and most of the patients required ventilator supports. Conclusio n: It is very important to predict and select the case by detailed clinical history and biochemical examination, so that better treatment and reduction of the mortality can be achieved.