Abstract
Gas-liquid chromatography analysis of triglyceride (TG) and phospholipid (PL) fatty acids was performed in several tissues of the rat during fetal and neonatal development and the effect of cretinism investigated. Liver and brown fat had a low TG content in the fetus, the TG of brown fat being characterized by a high proportion of saturated fatty acids; only saturated fatty acids were synthetized from glucose by brown fat fragments. The onset of suckling was followed by an immediate accumulation of TG in liver and brown fat, and the fatty acid pattern of these TG was modified, but in opposite directions; the proportion of arachidonic acid increased in the PL of all tissues. Propylthiouracil feeding of the mother from the day of birth induced an abnormal accumulation of TG in the brown adipose tissue of the rat by the time they had the syndrome of cretinism. The fatty acid pattern of these TG was similar to that of controls.
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