A Study of Nerve Conduction Test &amp; Other Hematological Parameters in Diabetics

Jasmin J Parmar ,Jitendra Patel

doi:10.37506/ijop.v8i1.13

Abstract

Background: Nerve conduction studies (NCS) are most sensitive, reliable and non-invasive investigation to detect diabetic neuropathy. Sensory nerves are more affected as compared to motor nerves in diabetic neuropathy. Understanding the Nerve conduction studies is useful for early detection polyneuropathy and prevention of its dreaded complications. Materials and Method: The present study was conducted among 30 subjects of type 2 Diabetic and 30 non diabetics subjects. Haematological parameters such as HbA1c, platelet count, prothrombin time, APTT, triglycerides, LDL and HDL levels were estimated. Motor nerve conduction velocity median , ulnar, common peroneal and posterior tibial nerve and sensory nerve conduction velocity median , ulnar and sural nerve were recorded. Result: Mean age of diabetic patients was 51±.4.8 year. Most of the subjects (86.7%) were male. Sensory nerve conduction of sural nerve was signiicantly reduced in diabetic patients as compared to non diabetic patients. SNCV of sural nerve showed deterioration with the duration of diabetes, poor glycemic control and patients with altered lipid profile. Conclusion: Nerve conduction velocity testing of sural nerve is useful for early detection of diabetic neuropathy and reduce the burden of complication and to improve the quality of life in diabetics.

Highlights

Diabetes mellitus (DM) is a metabolic disorder characterized by chronic hyperglycaemia with abnormalities in carbohydrate metabolism.[1]
Nerve conduction velocity testing of sural nerve is useful for early detection of diabetic neuropathy and reduce the burden of complication and to improve the quality of life in diabetics
Sensory nerves are more affected as compared to motor nerves in diabetic neuropathy. 5,6 Relationship between poor glycaemic control and DPN has been reported by various authors. 7,8 The Nerve conduction studies (NCS) is crucial for early detection and prevention of its dreaded complications of DPN.[9,10]

Summary

Introduction

Diabetes mellitus (DM) is a metabolic disorder characterized by chronic hyperglycaemia with abnormalities in carbohydrate metabolism.[1] In India, prevalence of diabetic peripheral neuropathy in Type 2 diabetic patients was 26.1%.2. Distal symmetric sensorimotor polyneuropathy is the most common clinical type of DPN. Three fourth of neurologically asymptomatic patients may have abnormal nerve conduction.[1] Age, male gender, duration of diabetes, glycated hemoglobin levels and insulin use increase risk of peripheral neuropathy .3. Nerve conduction studies (NCS) are most sensitive, reliable and non-invasive investigation to detect diabetic neuropathy. Sensory nerves are more affected as compared to motor nerves in diabetic neuropathy. Understanding the Nerve conduction studies is useful for early detection polyneuropathy and prevention of its dreaded complications

Methods

Results

Discussion

Conclusion