Abstract
Mutational phase III strains reduced caries in experimental animals. The proliferation in phase I was extremely inhibited in the presence of phase III in the oral cavity of hamsters, resulting in suppressed caries induction by phase I. In rats, the phase III strain induced from Str. mutans isolated from a rat could inhibit the growth of Str. mutans indigeneous in rats, and showed a caries-reducing effect, but the phase III strain induced from Str. mutans isolated from a human failed to exhibit the caries-reducing effect. There seemed to be a considerable degree of specificity between Str. mutans and the host.
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