Abstract
Cancer is a highly complex disease due to the disruption of tissue architecture. Thus, tissues, and not individual cells, are the proper level of observation for the study of carcinogenesis. Thus the shape and regularity of the epithelial connective tissue interface(ECTI),has classically been used to describe both physiological and pathological changes in the oral mucosa,including cancer. However, the description of ECTI has most often been subjective. The use of fractal geometry, has therefore been used to describe the irregularities of ECTI profiles taken from the oral mucosa both in normal and abnormal cases.Also the Pseudoepitheliomatous hyperplasia (PEH) of the covering epithelium mimics the squamous cell carcinoma invasion.PEH cells do not show marked atypia ,but the presence of pseudoinvasive pattern remains a diagnostic problem since several misdiagnosed cases have been reported. Similar diagnostic problems do occur sometimes between normal & dysplasia or dysplasia & squamous cell carcinoma. The aim of this study is to investigate the objective morphometric criteria to distinguish each entity separately ie. normal ,dysplasia ,pseudoepitheliomatous hyperplasia & squamous cell carcinoma .
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