Abstract
Isolation and Identification of Potential Antineoplastic Bioactive Phenolic Compounds in Malaysian HoneysNorjihada Izzah Ismail, Mohammed Rafiq Abdul Kadir, Razauden Mohamed Zulkifli
Highlights
Buprenorphine hydrochloride (BU) is chemically known as (6R, 7R, 14S)-17cyclopropylmethyl- 7, 8-dihydro-7-[(l S)-1-hydroxy-1, 2, 2 trimethylpropyl]-6-0-methyl-6, 14-ethano17-normorphine hydrochloride (USP, 2007; Drugbank, 2016; Sweetman, 2009; Ash et al, 1996)
BU-ME developed in the Centre for Advanced Research and Innovation (CARIn), Zim Laboratories, used for analytical method development
Method development and optimization BU being highly soluble in methanol i.e. 42.0 mg/mL, it is used as solvent for standard and sample preparation (Elephant Care International, 2016)
Summary
Buprenorphine hydrochloride (BU) is chemically known as (6R, 7R, 14S)-17cyclopropylmethyl- 7, 8-dihydro-7-[(l S)-1-hydroxy-1, 2, 2 trimethylpropyl]-6-0-methyl-6, 14-ethano17-normorphine hydrochloride (USP, 2007; Drugbank, 2016; Sweetman, 2009; Ash et al, 1996). BU in biological samples analyzed mainly using chromatographic methods such as gas chromatography with electron-capture detector (Everhart et al, 1997), HPLC with UV detector (Tebbett et al, 1985; Hackett et al, 1986); fluorescence detector (Liu et al, 2005; Garrett et al, 1985); electrochemical detector (Garcia-Fernandez et al, 2001) and some hyphenated techniques like HPLC-MS (Polettini et al, 1997; Moody et al, 2002; Pirnay et al, 2006; Rodriguez-Ross et al, 2007) As these methods reported for analysis of biological samples, these involve sample preparation steps consisting of extraction and/or derivatization before analysis. To improve bioavailability of BU, researchers formulate it into novel drug delivery systems like microemulsion, which contain excipients like oils, surfactants, cosurfactants etc Many of these components are known to absorb in the 200 – 250 nm region of UV spectrum (Baboota et al, 2007; Wuelfing et al, 2006; Johnson, 2013). According to the current ICH “Stability Testing Guidelines” Q1 A (R2), forced degradation studies of BU were carried out (ICH, 2003) to give additional information of stability of BU during formulation, analysis and storage (Reynolds et al, 2002)
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