Abstract
To find out the correlation of Meibomian gland and Tear film dysfunction with pterygium. Institution based prospective cross sectional study. 70 (seventy) patients with unilateral primary progressive nasal Pterygium and 70 healthy adults without any ocular pathology were selected as comparison group from the Ophthalmology outpatient department of Calcutta National Medical College and hospital, Kolkata for a duration of 6 months from January 2020 to June 2020. Meibomian gland dysfunction was measured by meibomian gland expression score and lid margin abnormality score. Tear film changes were measured by Ocular Surface Disease Index (OSDI) Score , Tear break up time (TBUT), Tear meniscus height(TMH), Schirmer’s test 1 (ST1) and Corneal flourescein staining in both pterygium and control group and comparisons were done to find out the significance in differences. The Categorical variables were analyzed with the help of Pearson Chi square test, Spearman rho Correlation, Man Whitney U Test and the continuous variables were analyzed with the help of Independent T test and Pearson Correlation coefficient. The level of significance was considered as 95% of confidence interval i.e. P value <0.05. OSDI score, TBUT, meibomian gland expression score, lid margin abnormality score and corneal fluoresce in staining were significantly higher in pterygium group than others (p<0.05) whereas TMH values although showed differences between the two groups but were not statistically significant. ST1 were normal in pterygium group though had significant difference with control. Meibomian gland function was altered in patient with Pterygium which is also associated with uncomfortable ocular symptoms due to tear film abnormalities.
Highlights
Pterygium is a common disorder of ocular surface in many parts of the world, affecting one eye or both the eyes, described as an ophthalmic enigma”. 1,2 The exact etiology and pathogenesis of pterygium remains unclear
Mean of Ocular Surface Disease Index (OSDI) in pterygium group was 24.80 which was significantly higher than comparison group 13.40 (p
Mean of Tear break up time (TBUT) in pterygium group was 6.97 sec compared to 10.47 sec in comparison group and the difference is highly significant
Summary
Pterygium is a common disorder of ocular surface in many parts of the world, affecting one eye or both the eyes, described as an ophthalmic enigma”. 1,2 The exact etiology and pathogenesis of pterygium remains unclear. 1,2 The exact etiology and pathogenesis of pterygium remains unclear. Pterygium is a common disorder of ocular surface in many parts of the world, affecting one eye or both the eyes, described as an ophthalmic enigma”. It is a fibro vascular growth of the conjunctiva, commonly encroaching onto the cornea. It causes corneal astigmatism, as well as ocular discomfort which may be due to dry eye. As well as ocular discomfort which may be due to dry eye It is a potentially blinding disease in the advanced stage due to invasion into the visual axis, which can have a significant impact on vision and may require surgery.[3] It causes cosmetic disfigurement. Its prevalence is high in the “pterygium belt” between 30 degrees north and 30 degrees south of the equator. 4
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