Abstract
Young male Wistar rats (75–80 g) were divided into 4 groups of 4 to 5 each. One group was maintained as control and the other groups received 25 ppm BHC mixed in the diet or 20% ethanol through water ad libitum or 25 ppm BHC + 20% ethanol. The rats were maintained on this regimen for 120 days and the toxicity was assessed by estimating the liver and serum enzyme activity such as, succinate dehydrogenase (SDH), lactate dehydrogenase (LDH), alkaline and acid phosphatase (ALP and ACP), aspartate and alanine aminotransferase (GOT and GPT). There was significant increase in the activity of liver and serum LDH, ALP, ACP, GOT and GPT in ethanol alone and ethanol + BHC fed rats, whereas, significant decrease in liver SDH activity was observed in ethanol + BHC fed rats. The consistent increase in liver and serum LDH, ALP, liver ACP and serum GOT levels in ethanol + BHC fed group compared to ethanol alone fed group indicates enhancement of toxicity due to interaction of ethanol and BHC.
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