Abstract
Trichinellosis is a serious zoonotic parasitic and globally endemic disease. Benzimidazole derivativesare apparently unable to kill encapsulated larvae and its effectiveness depends on solubility, dosage oftherapy, host biotransformation, selectivity patterns as well as onset of treatment after infection. Excretory-secretory (ES) proteins released by Trichinella induce a strong immune response when tested as avaccine. The current study investigated both therapeutic and protective effects of adult worm excretorysecretory protein (AW/ES), or larval excretory secretory protein (LES) on T. spiralis infected mice,conducted by parasitological, histopathological, immunohistochemical, serological and molecular investigations.Larval excretory secretory protein achieved more significant therapeutic and protectiveeffects than adult worm excretory secretory protein in experimentally infected mice, causing reductionin larval counts and decrease in pathological changes of both muscular and intestinal tissues. It increasedserum IgG OD values, decreased Foxp3 expressions and increased the mean cycle thres- holdvalues of muscular tissues but it had lesser effects on adult worm counts than albendazole.
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