Abstract
Seven boys were studied who had the clinical features of subacute sclerosing panencephalitis (SSPE) and whose brain histology was consistent with SSPE. Measles antigen was detected in the 7 brains by the direct fluorescent antibody method. Three out of the 7 boys had in their sera measles specific immunoglobulin M (IgM) which was detected by the indirect fluorescent antibody method and in 2 of these sera a prozone effect was noted. Two of the boys who had high titres of measles specific IgM also had serum IgM which reacted with canine distemper virus antigen, but the titres were 8 fold lower. None of the boys had detectable rinderpest specific IgM in their sera.
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