Abstract
To assess the diagnostic value of interleukin 6 (IL-6), IL-8 and tumor necrosis factor-α (TNF-α) as inflammatory markers in chronic obstructive pulmonary disease (COPD) patients. IL-6, IL-8 and TNF-α levels were measured by ELISA in the serum and the bronchoalveolar lavage (BAL) in 10 control participants and 25 mild and moderate COPD patients, whereas 25 patients with severe COPD were studied for the serum level of these inflammatory biomarkers. The mean value and SD of BAL and serum IL-6, IL-8 and TNF-α levels were significantly higher in COPD patients when compared with control participants; the serum level of these biomarkers were also significantly higher in severe compared with mild and moderate COPD patients. Increased srum and/or BAL IL-6, IL-8 and TNF-α can be used as biomarkers of the systemic inflammatory response in COPD patients, and their levels are correlated with the severity of COPD. Egypt J Broncho 2014 8:91–99
Highlights
Chronic obstructive pulmonary disease (COPD) is a preventable and treatable disease characterized by airflow limitation that is not fully reversible, usually progressive and is associated with an abnormal inflammatory response of the lungs to noxious particles or gases [1].Symptoms of COPD range from chronic cough, sputum production and wheezing to more severe symptoms, such as dyspnea, poor exercise tolerance and signs or symptoms of right-sided heart failure [2].IL-8 is a multifunctional chemokine involved in inflammation-mediated neutrophil infiltration and chemotaxis. [7] IL-8, known as CXCL8, is a CXC chemokine that is a potent chemoattractant for neutrophils
The mean value and SD of bronchoalveolar lavage (BAL) and serum IL-6, IL-8 and tumor necrosis factor-α (TNF-α) levels were significantly higher in COPD patients when compared with control participants; the serum level of these biomarkers were significantly higher in severe compared with mild and moderate COPD patients
The mean value and SD of BAL TLC, macrophage, lymphocyte, and neutrophil were significantly higher in group II when compared with group I (t-test < 0.001)
Summary
Chronic obstructive pulmonary disease (COPD) is a preventable and treatable disease characterized by airflow limitation that is not fully reversible, usually progressive and is associated with an abnormal inflammatory response of the lungs to noxious particles or gases [1].Symptoms of COPD range from chronic cough, sputum production and wheezing to more severe symptoms, such as dyspnea, poor exercise tolerance and signs or symptoms of right-sided heart failure [2].IL-8 is a multifunctional chemokine involved in inflammation-mediated neutrophil infiltration and chemotaxis. [7] IL-8, known as CXCL8, is a CXC chemokine that is a potent chemoattractant for neutrophils. Chronic obstructive pulmonary disease (COPD) is a preventable and treatable disease characterized by airflow limitation that is not fully reversible, usually progressive and is associated with an abnormal inflammatory response of the lungs to noxious particles or gases [1]. IL-8 is a multifunctional chemokine involved in inflammation-mediated neutrophil infiltration and chemotaxis. There has been increasing interest in using pulmonary biomarkers to understand and monitor the inflammation in the respiratory tract of patients with COPD; a biomarker refers to any molecule or material (cells, tissue), the measurement of which reflects the disease process. In COPD, several types of biomarkers have been measured and are related to the disease pathophysiology and the inflammatory or destructive process in the lung [3]
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