Abstract
Objectives:Human papillomavirus (HPV) is a major cause of cervical cancer in women. The characteristics of HPV infection vary; therefore, it is necessary to identify the most common HPV genotypes among a group of subjects when introducing a vaccine program. Currently, in the Yanbian Autonomous Region, no HPV vaccinations are not provided, and no data has been reported regarding HPV rates or genotype prevalence. We aimed to find the most suitable HPV vaccine for this region and reasons why no vaccine has been introduced. Methods:HPV genotyping of 200 Korean-Chinese women living in the Yanbian Autonomous Region who visited the hospital for annual health examination was done. We also checked main factors necessary for HPV vaccine administrative system; (1) vaccine manufacturers in China, (2) vaccine importers, (3) vaccine suppliers, (4) applicable vaccine laws, (5) the HPV vaccine permit system in Jilin Province, and (6) vaccination hospital facilities-were assessed by direct inquiry and search. Results:The results showed that HPV genotypes 52, 58, 16, 53, and 33 were the most common among Korean-Chinese women. These results differed from those previously reported for Korean or Chinese women. All elements necessary for introduction of HPV vaccine were prepared, but there is no HPV vaccination plan based on epidemiological investigation. Conclusions:Gardasil® 9 should be the most suitable vaccine for Korean-Chinese women with HPV infection and cervical cancer in this region considering the prevalence of certain genotypes. Governments and medical institutions should take an active stance on HPV vaccination to lower the incidence of cervical cancer here. Our study may serve as an important reference for introducing a Chinese government program designed to prevent cervical cancer.
Highlights
Cervical cancer is one of the leading causes of death for women and occurs frequently around the world (Torre et al, 2015)
To find out why no vaccine has been introduced to the Yanbian Autonomous Region, we studied the process of vaccine introduction, including vaccine manufacturing, vaccine supply, vaccination permit authority, applicable vaccine law, conditions for vaccination facilities, first aid for accidents, compensation rules, and supervision rules (Figure 1)
According to this study’s results, the Human papillomavirus (HPV)-positive rate among Korean-Chinese women in the Yanbian Autonomous Region, Jilin Province, China was higher than the high-risk HPV-positive rate in 37 cities across China, lower than the HPV-positive rate in Gangwon and Seoul, Korea, and slightly higher than the HPV-positive rate in 13 cities across Korea as well as in Daegu and Daejeon
Summary
Cervical cancer is one of the leading causes of death for women and occurs frequently around the world (Torre et al, 2015). The incidence of cervical cancer in China has continued to rise by 11.3 % annually on average for the past several years. According to the 2015 Chinese Cancer Registry Annual Report, 98,900 people develop cervical cancer each year, with 30,500 deaths (Chen et al, 2016). While many studies have reported HPV infection data for China as a whole, no study of the HPV positive rates and genotypes has been conducted on Korean-Chinese women living in the Yanbian Autonomous Region
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
