Abstract
Introduction: Osteoarthritis (OA) is the common cause of musculoskeletal disability and pain. Osteoarthritis (OA) is a chronic disease characterized by a loss of articular cartilage and changes of the subchondral bone. Lower levels of vitamin D were associated with greater knee pain, poor quadriceps function with poor physical function. Several studies have documented that vitamin D supplementation increases muscle strength, improve physical performance, and decreases risk of falls among older people with low level of serum vitamin D. Materials &Methods:This present study was conducted at the outpatient clinic of the Department ofOrthopedics at Maheswara Medical college & Hospital, Sangareddy during a February–December 2017 study period.The inclusion criteria were that the participants had symptomatic knee OA and low vitamin D status (25(OH)D < 30 ng/mL). Results:Data were analyzed using SPSS Statistics version 22 (SPSS, Inc., Chicago, IL, USA). Comparisonof baseline vs. post-vitamin Dsupplementation data was performed by paired t-test. One-wayrepeated-measurement ANOVA was used to test the time differences in muscle strength and physicalperformance. A p-value less than 0.05 for differences and the values were considered to be statistically significant.Dominant grip strength (p = 0.01) and overall physical performance, such as gait speed (p < 0.001),TUGT (p < 0.001), STS (p < 0.001), and 6MWT (p < 0.001), significantly improved after vitamin. Conclusion:Nevertheless, vitamin D supplementation is a safe and inexpensive way to improve muscle strength and physical function in this population. Based on these findings, we recommend vitamin D supplementation in knee OA patients that have poor physical function.
Highlights
Osteoarthritis (OA) is the common cause of musculoskeletal disability and pain
In the above study, regarding muscle strength and physical performance, we found that knee OA patients significantly improved grip strength and physical performance, but did not improve knee extension force
Our results suggest that 40,000 IU of vitamin D supplementation reduced oxidative protein damage, improved quality of life, and improved grip strength and physical performance
Summary
Osteoarthritis (OA) is the common cause of musculoskeletal disability and pain. Osteoarthritis (OA) is a chronic disease characterized by a loss of articular cartilage and changes of the subchondral bone. Conclusion: vitamin D supplementation is a safe and inexpensive way to improve muscle strength and physical function in this population. Based on these findings, we recommend vitamin D supplementation in knee OA patients that have poor physical function. Several studies have documented that vitamin D supplementation increases muscle strength, improves physical performance, and decreases risk of falls among older people with low level of serum vitamin D [3]
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