A STUDY OF CORRELATION BETWEEN GAMMA GLUTAMYL TRANSFERASE AND METABOLIC SYNDROME

Abstract

CONTEXT:The metabolic syndrome ( Syndrome X, or insulin resistance syndrome) is a combination of several risk factors that contribute to atherosclerotic cardiovascular disease (ASCVD). Elevated blood pressure, triglycerides, hyperglycemia, waist circumference and low HDL- cholesterol are all symptoms of accelerated dyslipidemic atherogenesis. Glutamyl transferase (GGT) has long been thought to be a biomarker for hepatic and biliary illness and alcoholic related disease. GGT is required for the extracellular catabolism of glutathione, which is the most important thiol antioxidant in humans.It co localizes with oxidised low density lipoprotein (LDL) and foam cells in the atheromatous core of coronary plaques. GGT can be a proinammatory sign. GGT was found to be a prognostic marker for Metabolic syndrome, CVD, and heart failure .AIM: Study of Gamma glutamyltransferase in metabolic syndrome patients. MATERIALS AD METHODS: A sample size of 100 patients admitted in medicine and other departments in nri general hospital are included in study Qualitative data was expressed in frequencies and percentages a STASTISTICAL ANALYSIS: nd Quantitative data in mean and standard deviation. Non parametric statistics i.e. Chisquare test was used to nd the signicant association between the two qualitative variables. Independent t test and ANOVA were used to nd the statistical signicance between quantitative variables. Pearson correlation coefcient was used to nd correlation between two variables. p value of <0.05was considered statistically signicant. CONCLUSION: It should be highlighted that elevated levels of GGT are not the only hepatic biomarker of hepatic steatosis, as evidenced by ndings from several research. lines of evidence point to a link between high GGT levels in the blood and the metabolic syndrome. As a result, higher GGT levels are associated with increased insulin resistance and a higher risk of type 2 diabetes .