Abstract

The clinicopathologic variables including mode of infiltrative growth were investigated by multivariate analysis using quantification theory II to evaluate multivariately their effects on the hepatic metastasis and to discriminate liver metastasis after curative resection for advanced colorectal cancer. Subject were 194 patients with advanced colorectal who had hepatic metastasis (107 synchronous and 87 metachronous) and 261 patients with the disease who were free from any recurrence for more than 5 years. The factor with the greatest influence was lymph node metastasis followed by the depth of invasion. Mode of infiltrative growth was though to be one of the useful indicators of hepatic metastasis after curative resection of colorectal cancer. Discrimination of hepatic metastasis was achieved with 75.2% success rate in the cases of Dukes B and Dukes C after curative resection. Discriminative analysis using quantification theory II was thought to be useful for the prediction of liver metastasis after curative resection for colorectal cancer.

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