A STUDY OF CLINICAL PROFILE OF ACUTE PANCREATITIS PATIENTS WITH EMPHASIS ON MODIFIED CT SEVERITY INDEX AND SERUM PROCALCITONIN AS MARKERS FOR ASSESING SEVERITY

Abstract

Aim: To study the clinical prole of acute pancreatitis patients and MCTSI as an index for predicting severity, I.C.U admissions and mortality of acute pancreatitis cases and also to compare it with serum procalcitonin in predicting severity. This study was conducted Material and Methods: in the Department of Medicine and Gastroenterology, Gauhati Medical College and Hospital for a period of one year. A total 98 acute pancreatitis were included and their clinical prole was studied. MCTSI score was calculated for all the patients and used to predict severity, I.C.U admissions and mortality. MCTSI was also compared with serum procalcitonin in assessing severity. Male preponderance was noted in the study. The Results: peak incidence of disease was noted in the 3rd decade of life. Pain abdomen was found to be the most prominent clinical feature. Alcohol consumption was found to be the most common etiological factor. It was observed that mild, moderate and severe acute pancreatitis according to ATLANTA CLASSIFICATION correlated well with MCTSI scoring system. All the 19 severe acute pancreatitis cases had an MTCSI score in the severe range (p value of 0.0001 - statistically signicant). The mortality rate was signicantly higher in severe acute pancreatitis i.e. 57.89% as compared to mild and moderate acute pancreatitis (p value of 0.0001). The I.C.U admission rate in mild acute pancreatitis was 4.17% as compared to 100 % in severe acute pancreatitis (p value 0.0001). Statistically signicant difference was observed in serum procalcitonin levels (mean ±SD ng/dl) of mild, moderate and severe acute pancreatitis cases as per MCTSI scoring system (p value of 0.0001). Among the 98 cases, Conclusion: male to female ratio was 2.05:1. The most common cause of acute pancreatitis was ethanol abuse. The most prominent symptom was pain in the abdomen followed by vomiting. MCTSI fared well in predicting severity, mortality and I.C.U admissions in acute pancreatitis cases. The relationship of MCTSI score with serum procalcitonin in predicting severity was found to be signicant