Abstract

Tissue eosinophilia has been demonstrated in the skin sites of allergic individuals following application of the allergen. The eosinophilia was greatest with the allergen which clinically seemed to be responsible for the patient's symptoms. Phenergan appeared to increase skin window eosinophilia, although this conclusion must await further study. Application of a topical steroid failed to produce a consistent alteration in eosinophil counts, while oral steroid therapy abolished eosinophilia. The steroid probably exerted its effects by markedly reducing the blood eosinophil level. The suspected chemical mediators of eosinophilia in a skin abrasion were investigated. These studies demonstrated that histamine was capable of inducing tissue eosinophilia in allergic subjects but not in normals, implicating skin-sensitizing antibody as a further prerequisite for the production of tissue eosinophilia.

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