Abstract
Objective To investigate brain-derived neurotrophic factor(BDNF)and tissue-type plasminogen activator(tPA)levels in geriatric depression.Methods Plasma BDNF and tPA levels were determined in 28 patients with geriatric depression and 30 healthy controls by using ELISA.The severity of depression was measured with the Hamilton Depression Rating Scale(HDRS).Results Plasma BDNF levels were significantly lower in patients with geriatric depression[(864.23±198.41)pg/ml]than in normal control subjects[(958.83±150.20)pg/ml](P＜0.05).There Was a heightening tendency after treatment.There were no significant differences of tPA levels between pre-treatment[(13.33±5.35)ng/ml],post-treatment[(11.83±5.02)ng/ml]in patients with geriatric depression and in normal control subjects[(12.53±5.35)ng/ml].There were no significant correlations between BDNF and tPA in untreated patients with geriatric depression.Conclusions Plasma BDNF level in geriatric depression may be considered as a biological marker.There were a complicated mediated processes between BDNF and tPA. Key words: Major depression; Brain-derived neurotrophic factor; Tissue-type plasminogen activator; Elderly
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