Abstract
目的 探讨孤独症儿童局部脑血流灌注的特点.方法 对56例孤独症患儿进行脑([99m]Tc)-ECD单光子发射型电子计算机断层显像检测,测量并定性分析局部脑血流灌注的改变以及发生的部位.结果 (1)42例孤独症患儿存在局部脑血流低灌注,发生率为75%,主要表现在双侧海马回、颞叶、额叶、岛叶、扣带回、枕叶等部位,其中发生在左侧大脑半球有15例(15/42),右侧大脑半球有11例(11/42),两者差异无显著性(x2=0.891,P=0.345).(2)将孤独症患儿按年龄分组,＜3岁组和≥7岁组额叶低灌注发生率较3～5岁组(5/22)、5～7岁组(3/22)显著降低(x2=7.793,P=0.045),而总的脑血流低灌注发生率四个年龄组差异无显著性(x2=3.772,P=0.287).结论 孤独症患儿存在海马回、颞叶、额叶等多区域的脑血流低灌注,发生部位未有大脑半球侧化现象;提示孤独症的发生与上述部位的脑功能改变有关,且患儿3～7岁阶段可能存在暂时的大脑额叶功能不全。
Published Version
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