A study of bone–vascular axis in health and disease

Abstract

ObjectivesThe aim was to study bone–vascular axis in health and disease.Data sourcesMedline databases (PubMed and MedScape) and all materials available in the internet were searched. The search was performed in September 2021.Study selectionThe initial search presented 120 articles. The number of studies that met the inclusion criteria was 21. The articles included both sexes and patients with bone–vascular disease.Data extractionIf the studies did not fulfill the inclusion criteria, they were excluded. Data from each eligible study were independently abstracted in duplicate using a data collection form to capture information on study characteristics, interventions, and quantitative results reported for each outcome of interest.Data synthesisSignificant data were collected. Then a structured review was performed.FindingIn total, 21 potentially relevant publications were included; it was found that cardiovascular and bone disease are pathophysiologically interrelated.ConclusionsCardiovascular and bone disease are pathophysiologically interrelated, even though a full understanding of the mechanisms underlying this relationship is still lacking. A better understanding of the biological link between the two processes could lead to the development of new compounds that act on both vessels and bone. Meanwhile, it would seem reasonable to consider cardiovascular disease screening in patients with advanced bone demineralization, as well as careful monitoring for signs and symptoms of cardiovascular disease in chronic kidney disease patients.