Abstract
Background: In this study was carried out to determine the relation between serum levels of Folic Acid and preeclampsia among pregnant women.
 Methods: Methods- Hospital based comparative study was conducted at Department of Obstetrics and Gynaecology, SMS medical college, Jaipur.
 Results: In PIH group, 20.00% women folic acid level was 3.1-7.8 ng/ml, 40.00% women folic acid level was 7.9-12.6 ng/ml, 35.00% women folic acid level was 12.7-17.5 ng/ml and 5.00% women folic acid level was 17.6-20.00 ng/ml. In normotensive group, 5.00% women folic acid level was 3.1-7.8 ng/ml, 25.00% women folic acid level was 7.9-12.6 ng/ml, 50.00% women folic acid level was 12.7-17.5 ng/ml and 20.00% women folic acid level was 17.6-20.00 ng/ml.
 Conclusion: We conclude that folic acid is not the only element in preventing the preeclampsia, however, its serum level in case group is significantly less than control group.
 Keywords: Eclampsia, Folic acid, Hypertension
Highlights
Pre-eclampsia is a progressive, multisystemic disorder characterized by triad of high blood pressure to the extent of 140/90 mm Hg or more, edema and proteinuria, developing after 20 weeks of pregnancy. 1 It is one of the most common complications during pregnancy and the leading cause of both maternal and perinatal morbidity and mortality worldwide.[2]Incidence of preeclampsia worldwide is around 5-10% of all pregnancies,[5] and in developing countries around 418%.3-4 It is much more common in women who are pregnant for the first time,[9] and its frequency drops significantly in second pregnancies
We conclude that folic acid is not the only element in preventing the preeclampsia, its serum level in case group is significantly less than control group
Many studies have been performed about Folic Acid deficiency during pregnancy and increasing the of neural tube defects has been reported that 70% of these defects could be prevented through fortifying the foodstuff with folate besides the effect of daily consumption of Folic Acid in prevention from miscarriage, placenta abruption, improvement of fetus growth, reduction of cleft and palate risk have been documented,[8] many contradictory results have been published about the role of Folic Acid in preeclampsia
Summary
Pre-eclampsia is a progressive, multisystemic disorder characterized by triad of high blood pressure to the extent of 140/90 mm Hg or more, edema and proteinuria, developing after 20 weeks of pregnancy. 1 It is one of the most common complications during pregnancy and the leading cause of both maternal and perinatal morbidity and mortality worldwide.[2]. Many studies have been performed about Folic Acid deficiency during pregnancy and increasing the of neural tube defects has been reported that 70% of these defects could be prevented through fortifying the foodstuff with folate besides the effect of daily consumption of Folic Acid in prevention from miscarriage, placenta abruption, improvement of fetus growth, reduction of cleft and palate risk have been documented,[8] many contradictory results have been published about the role of Folic Acid in preeclampsia. Considering the high rate of preeclampsia and the importance of maternal, fetal and infancy complications resulting from it and considering the importance of Folic Acid consumption during pregnancy and its probable role in prevention from preeclampsia, this study was carried out to determine the relation between serum levels of Folic Acid and preeclampsia among pregnant women
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