Abstract
Of the numerous theories advanced in explanation of the reactions and fatalities following the intravenous injection of solutions of arsphenamin, considerable attention has been given to those based on the formation of precipitates in the blood which may result in pulmonary embolism and the production of immediate symptoms and even death. REVIEW OF LITERATURE As early as 1911, Michaelis 1 suggested that precipitates found in the blood in vivo may be responsible for fatalities following the intravenous injection of arsphenamin and a little later Miessner 2 showed that mixtures of acid solutions of arsphenamin and defibrinated blood or horse serum in test tubes produced heavy precipitates. When an alkaline solution of arsphenamin was used, he failed to obtain these precipitates. Schottmuller 3 reported the same results from mixtures in vitro of acid and of alkaline solutions of arsphenamin and blood plasma. Both Miessner and Schottmuller suggested that these precipitates may
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
