Abstract
Doxycycline hydrochloride is a broad spectrum antibiotic sensitive against a very large number of microorganisms. Since it causes less gastric irritation and can be administered once daily (initially some times twice daily), physicians are now choosing Doxycycline hydrochloride in place of tetracycline in many cases. Because of its dose advantage and effectiveness, it is being used very frequently worldwide. In Bangladesh, many pharmaceutical companies are manufacturing Doxycycline hydrochloride. This research project is aimed at investigating the antimicrobial potency of the Doxycycline hydrochloride capsules marketed by various pharmaceutical companies in Khulna city. Collected antibiotics were tested against E. coli and S. aureus through disc diffusion method. In this method paper disc were made to soak 30 pg of active ingredient and were placed on the agar plates previously seeded with E. coli and 5. aureus. The drug diffused onto the media and killed the bacteria they encounter. The diameter of the clear zone formed by the paper disk as well as the standard antibiotics disk were measured which reflects the potency of the Doxycycline hydrochloride powder.
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