Abstract
Abstract Adult male rats were given 500 r total body x-irradiation with and without lead shielding of the spleen. Twenty-four hours later these rats and normal controls were given a single injection of I 131 -labeled typhoid vaccine intravenously. Blood stream clearance, tissue distribution, and excretion of I 131 were studied. The histologic reaction to antigenic stimulation was followed at intervals of one, four, and six days after antigen injection. There was no difference in rate of phagocytosis, tissue localization, or rate of disappearance of antigen from the tissues in the three groups of animals. Radioautographs showed localization of antigen in the red pulp of the spleen, in the mantle of cells around the Malpighian corpuscles and focally in the pulp. The histologic reaction of the spleen following antigenic stimulation in normal and spleen-shielded animals consisted of hyperplasia of the red pulp and increase in pyronin staining of the cells. This pattern was not observed in irradiated animals. The significance of these findings with regard to the mechanism of irradiation damage to antibody formation is discussed.
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