A study of AKI in pregnancy and puerperium

M Gayathiri,Arul Arul,S Suganya

doi:10.18231/j.ijogr.2020.074

M Gayathiri, Arul Arul + Show 1 more

Open Access

https://doi.org/10.18231/j.ijogr.2020.074

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Abstract

Pregnancy related acute kidney injury is a common occurrence and is associated with substantial maternal mortality and morbidity in developing countries. The incidence of pregnancy related acute kidney injury in developing countries from 4% to 36%; it varies widely across the world. Acute kidney injury in pregnancy bears a high risk of bilateral cortical necrosis and consequently chronic renal failure. Study aimed to evaluate the preventable causes, contributing factors responsible for pregnancy related acute kidney injury and to assess the outcome of patients with pregnancy related acute kidney injury during pregnancy and puerperium.

Highlights

Acute kidney injury is rare in women during pregnancy and puerperium; it is related to increased morbidity and mortality rates
3 Other major causes in developing countries include sepsis, severe hemorrhage, whereas primary renal disease, thrombotic microangiopathy & acute fatty liver of pregnancy are more common in developed nations
Acute kidney injury in pregnancy bears a high risk of bilateral renal cortical necrosis and chronic

Summary

Introduction

Acute kidney injury is rare in women during pregnancy and puerperium; it is related to increased morbidity and mortality rates. The incidence of acute renal failure during pregnancy has declined in both developed and developing countries. The incidence of pregnancy related acute kidney injury in developing countries from 4% to 36%, 1 it varies widely across the world, with reported incidence of 1 in 20,000 pregnancies in developed countries. Other major causes in developing countries include sepsis, severe hemorrhage, whereas primary renal disease, thrombotic microangiopathy & acute fatty liver of pregnancy are more common in developed nations. Pregnancy unmasks underlying primary renal disease or modifies the course of preexisting renal disease. Acute kidney injury in pregnancy bears a high risk of bilateral renal cortical necrosis and chronic renal failure. The etiology of PR-AKI varies based on the country of origin, in most regions, including low income countries, preeclampsia & eclampsia account for 5 to 20% of cases. 3 Other major causes in developing countries include sepsis, severe hemorrhage, whereas primary renal disease, thrombotic microangiopathy & acute fatty liver of pregnancy are more common in developed nations. 4 Pregnancy unmasks underlying primary renal disease or modifies the course of preexisting renal disease.

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