Abstract

This study has compared the incidence of adverse reactions to individual doses of thiacetazone of 150 mg, 225 mg, 300 mg, 375 mg, 450 mg, 525 mg and 600 mg with those reported with a placebo. The investigation was conducted “blind”, the patients and supervisory staff being unaware of the details of the experimental design and what any individual dose of medicament was, and the co-ordinator, also, was unaware of the latter. Adverse reactions were reported in 2. 3 per cent of 2589 doses of thiacetazone and 1.6 per cent of 568 doses of placebo, nearly all being mild. All the doses of thiacetazone studied were well tolerated.

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