A Study of Adverse Drug Reactions Associated With Antihypertensives in a Tertiary Care Teaching Hospital

Abstract

Background Hypertension is a common chronic medical condition which is identified as the 3rd leading risk factor for global burden of diseases. According to Joint National Committee guidelines hypertension is defined as elevated systolic blood pressure of ge140mmHg or diastolic blood pressure of ge90mmHg.Objective The objective of this study was to analyse the adverse drug reaction associated with anti-hypertensives.Materials and Methods A prospective observational study was carried out for a period of 6 months in an inpatient department in SSIMSampRC a tertiary care teaching hospital Davangere. The data was collected from the case sheets of all inpatients taking at least one antihypertensive.Results Out of 150 patients 16 patients 10.66 experienced with adverse drug reaction. The commonly found adverse drug reaction was hydrochlorothiazide induced hyponatremia in 8 50 patients.Conclusion During this study diuretics were found to be the most frequently associated class of drug with ADRs and hydrochlorothiazide induced hyponatremia was found to be the frequently observed ADR. The study also suggested that ADR monitoring needs to be done in hospital settings continuously so that the harmful effect caused by different antihypertensive could be identified prevented and documented.